The influence of poly(ethylene glycol) ether tetrasuccinimidyl glutarate on the structural, physical, and biological properties of collagen fibers

Sanami, Mohammad, Sweeney, India R., Shtein, Zvi, Meirovich, Sigal, Sorushanove, Anna, Mullen, Anne Maria Aria, Miraftab, Mohsen ORCID: 0000-0002-6333-3852, Shoseyov, Oded, O'Dowd, Colm, Pandit, Adhay and Zeugolis, Dimitrios I. (2016) The influence of poly(ethylene glycol) ether tetrasuccinimidyl glutarate on the structural, physical, and biological properties of collagen fibers. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 104 (5). pp. 914-922. ISSN 1552-4981

Full text not available from this repository.
Official URL: http://onlinelibrary.wiley.com/journal/10.1002/(IS...

Abstract

Various chemical, natural, or synthetic in origin, crosslinking methods have been proposed over the years to stabilise collagen fibers. However, an optimal method has yet to be identified. Herein, we ventured to assess the potential of 4-star poly(ethylene glycol) ether tetrasuccinimidyl glutarate, as opposed to glutaraldehyde (GTA), genipin and carbodiimide, on the structural, physical and biological properties of collagen fibers. The 4-star poly(ethylene glycol) ether tetrasuccinimidyl glutarate induced an intermedium surface smoothness, denaturation temperature and swelling. The 4-star poly(ethylene glycol) ether tetrasuccinimidyl glutarate fibers had significantly higher stress at break values than the carbodiimide fibers, but significantly lower than the GTA and genipin fibers. With respect to strain at break, no significant difference was observed among the crosslinking treatments. The 4-star poly(ethylene glycol) ether tetrasuccinimidyl glutarate fibers exhibited significantly higher cell metabolic activity and DNA concentration that all other crosslinking treatments, promoted consistently cellular elongation along the longitudinal fiber axis and by day 7 they were completely covered by cells. Collectively, this work clearly demonstrates the potential of 4-star poly(ethylene glycol) ether tetrasuccinimidyl glutarate as collagen crosslinker.

Item Type: Article
Divisions: University of Bolton Research Centres > Institute for Materials Research and Innovation
Depositing User: Tracey Gill
Date Deposited: 10 Nov 2016 09:06
Last Modified: 08 Mar 2018 09:58
Identification Number: 10.1002/jbm.b.33445
URI: http://ubir.bolton.ac.uk/id/eprint/948

Actions (login required)

Edit Item Edit Item