Absorbent alginate fibres modified with hydrolysed chitosan for wound care dressings - II. Pilot scale development

Sweeney, India R. and Miraftab, Mohsen and Collyer, Graham J. (2014) Absorbent alginate fibres modified with hydrolysed chitosan for wound care dressings - II. Pilot scale development. Carbohydrate polymers, 102 (1). pp. 920-927. ISSN 0144-8617

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Official URL: http://www.sciencedirect.com/science/journal/01448...

Abstract

Fibres have been used extensively in wound dressing applications as they provide a high surface area for absorption, ease of fabrication and softness. It is common practice for commercial wound dressings to be produced from natural materials, such a marine polysaccharides, as they are predominantly biocompatible, non-toxic, and often display bioactive properties, such as inherent antimicrobial activity. In this study hydrolysed chitosans were utilised as a sole coagulant for the production of alginate-chitosan fibres via a one-step, direct wet-spinning extrusion process. The levels of chitosan incorporated into the fibres were analysed quantitatively via elemental analysis and qualitatively by staining using Amido Black 10B. It was estimated that the fibres contained between 4.50 and 5.10% (wt.%) chitosan. The presence of chitosan improved tensile properties such as elongation and tenacity of the base alginate fibres. The increased incorporation of chitosan into the fibres also improved the absorption of the fibres in both saline and distilled water; reaching maximum of >30 g/g and >50 g/g, respectively. This work suggests that the observed hydrolysed chitosan content within the fibre may be optimal for the preparation of a novel fibre for wound care application.

Item Type: Article
Additional Information: Full text of this article is not available in this repository.
Uncontrolled Keywords: Absorbent; Alginate; Chitosan; Gelling; PEC; Wet-spinning; Wound dressing
Subjects: T Technology > T Technology (General)
Divisions: University of Bolton Research Centres > Institute for Materials Research and Innovation
Depositing User: Sarah Taylor
Date Deposited: 24 Nov 2015 14:41
Last Modified: 24 Nov 2015 14:42
Identification Number: 10.1016/j.carbpol.2013.10.053
URI: http://ubir.bolton.ac.uk/id/eprint/769

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