Small diameter helical vascular scaffolds support endothelial cell survival.

Parikh, Vijay, Kadiwala, Juned, Bastida, Araida Hidalgo, Holt, Cathy, Sanami, Mohammad ORCID: 0000-0002-8671-4180, Miraftab, Mohsen ORCID: 0000-0002-6333-3852, Shakur, Rameen and Azzawi, May (2018) Small diameter helical vascular scaffolds support endothelial cell survival. Nanomedicine : nanotechnology, biology, and medicine, 14 (8). ISSN 1549-9634

Scaffold paper 1-s2.0-S1549963418305094-main.pdf - Accepted Version
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There is an acute clinical need for small-diameter vascular grafts as a treatment option for cardiovascular disease. Here, we used an intelligent design system to recreate the natural structure and hemodynamics of small arteries. Nano-fibrous tubular scaffolds were fabricated from blends of polyvinyl alcohol and gelatin with inner helices to allow a near physiological spiral flow profile, using the electrospinning technique. Human coronary artery endothelial cells (ECs) were seeded on the inner surface and their viability, distribution, gene expression of mechanosensitive and adhesion molecules compared to that in conventional scaffolds, under static and flow conditions. We show significant improvement in cell distribution in helical vs. conventional scaffolds (94% ± 9% vs. 82% ± 7.2%; P < 0.05) with improved responsiveness to shear stress and better ability to withhold physiological pressures. Our helical vascular scaffold provides an improved niche for EC growth and may be attractive as a potential small diameter vascular graft.

Item Type: Article
Additional Information: This is an Author Accepted Manuscript of a paper accepted for publication in Nanomedicine: Nanotechnology, Biology and Medicine, published by and copyright Elsevier.
Uncontrolled Keywords: Endothelial, Helical, Scaffold, Shear stress, Vascular
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine
Divisions: School of Engineering > Biomedical and Medical Engineering
University of Bolton Research Centres > Institute for Materials Research and Innovation
SWORD Depositor: JISC Publications Router
Depositing User: JISC Publications Router
Date Deposited: 26 Sep 2018 08:21
Last Modified: 04 Jun 2020 10:17
Identification Number: 10.1016/j.nano.2018.08.005

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